Renal handling of fleroxacin in rabbits, dogs, and humans

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Published in:	Antimicrobial Agents and Chemotherapy Vol. 34; no. 1; pp. 58 - 64
Main Authors:	SHIBA, K, SAITO, A, UCHIDA, H, SHIMADA, J, HORI, S, KAJI, M, MIYAHARA, T, KUSAJIMA, H, KANEKO, S, SAITO, S, OOIE, T
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-01-1990
Subjects:	Adult Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Blood Proteins - metabolism Ciprofloxacin Ciprofloxacin - analogs & derivatives Ciprofloxacin - pharmacokinetics Ciprofloxacin - urine Creatinine - blood Dogs Fleroxacin Glomerular Filtration Rate Humans Kidney Kidney - metabolism Kinetics Male Medical sciences Pharmacology. Drug treatments Probenecid - pharmacology Protein Binding Rabbits Research Article Species Specificity Renal function Volunteer Rabbit Clearance Uricosuric agent Kidney Proteins Stopped flow method Serum Drug interaction Dog Human Fissipedia Carnivora Single dose Elimination Oral administration Lagomorpha Vertebrata Biological fixation Mammalia Animal Antibacterial agent Pharmacokinetics Comparative study
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Abstract	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
AbstractList	The renal handling of fleroxacin was studied by renal clearance and stop-flow techniques in rabbits and dogs and by analyzing the pharmacokinetics with and without probenecid in humans. In rabbits the excretion ratios (fleroxacin intrinsic renal clearance/glomerular filtration rate) were greater than unity (2.01) without probenecid and were decreased to a value below unity (0.680) with probenecid. In dogs, on the other hand, the excretion ratios were less than unity (0.608 and 0.456) both without and with probenecid, and so were not affected by probenecid. This fact suggested that fleroxacin was excreted into urine by both glomerular filtration and renal tubular secretion in rabbits, but only by glomerular filtration in dogs, accompanied by partial renal tubular reabsorption in both species; these mechanisms were also supported by stop-flow experiments. In humans probenecid treatment induced increases in the elimination half-life and area under the serum concentration-time curve and decreases in apparent serum clearance, renal clearance, and urinary recovery of fleroxacin. The excretion ratio without probenecid was 1.13, which was significantly decreased to 0.750 with probenecid. These results indicated that both renal tubular secretion and reabsorption contributed to renal excretion of fleroxacin in humans. The contribution of tubular secretion was species dependent and was extensive in rabbits, minimal in dogs, and moderate in humans. Renal tubular reabsorption was commonly found in every species. The long elimination half-life of fleroxacin in humans might be explained by its small total serum clearance and small renal clearance, which are attributed to less tubular secretion and more tubular reabsorption. Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
Author	S Kaneko M Kaji S Saito T Ooie A Saito T Miyahara J Shimada S Hori K Shiba H Kusajima
AuthorAffiliation	Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
AuthorAffiliation_xml	– name: Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
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Keywords	Renal function Volunteer Rabbit Clearance Uricosuric agent Kidney Proteins Stopped flow method Serum Drug interaction Dog Human Fissipedia Carnivora Single dose Elimination Oral administration Lagomorpha Vertebrata Biological fixation Mammalia Animal Antibacterial agent Pharmacokinetics Comparative study
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Snippet	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... The renal handling of fleroxacin was studied by renal clearance and stop-flow techniques in rabbits and dogs and by analyzing the pharmacokinetics with and...
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SubjectTerms	Adult Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Blood Proteins - metabolism Ciprofloxacin Ciprofloxacin - analogs & derivatives Ciprofloxacin - pharmacokinetics Ciprofloxacin - urine Creatinine - blood Dogs Fleroxacin Glomerular Filtration Rate Humans Kidney Kidney - metabolism Kinetics Male Medical sciences Pharmacology. Drug treatments Probenecid - pharmacology Protein Binding Rabbits Research Article Species Specificity
Title	Renal handling of fleroxacin in rabbits, dogs, and humans
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