High-Sensitivity NanoLC−MS/MS Analysis of Urinary Desmosine and Isodesmosine

Chronic obstructive pulmonary disease (COPD) is characterized by the degradation of elastin, the major insoluble protein of lung tissues. The degradation of elastin gives rise to desmosine (DES) and isodesmosine (IDES), two major urinary products typified by a hydrophilic pyridinium-based cross-link...

Full description

Saved in:

Bibliographic Details
Published in:	Analytical chemistry (Washington) Vol. 81; no. 5; pp. 1881 - 1887
Main Authors:	Boutin, Michel, Berthelette, Carl, Gervais, François G, Scholand, Mary-Beth, Hoidal, John, Leppert, Mark F, Bateman, Kevin P, Thibault, Pierre
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-03-2009
Subjects:	Analytical chemistry Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, Liquid - methods Chronic obstructive pulmonary disease Desmosine - urine Elastin - analysis Exact sciences and technology Humans Ion chromatography Isodesmosine - urine Limit of Detection Lungs Mass spectrometry Mass Spectrometry - methods Other chromatographic methods Proteins Smoking Spectrometric and optical methods Tandem Mass Spectrometry - methods Urine Urine Tissue Sensitivity Sensitivity analysis Internal standard Detection limit Mass spectrometry MS/MS Liquid chromatography By product Monitoring Protein Quantitative analysis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!