On-Demand Drug Delivery System Using Micro-organogels with Gold Nanorods

In this study, we designed a biocompatible drug carrier: micro-organogels prepared by emulsification using vegetable oils and self-assembled gelator fibers. Flurbiprofen was chosen as a hydrophobic model drug and is classified as a nonsteroidal anti-inflammatory drug. In the absence of NIR light, fl...

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Bibliographic Details
Published in:	ACS medicinal chemistry letters Vol. 7; no. 12; pp. 1087 - 1091
Main Authors:	Park, Honglual, Yang, Soojung, Kang, Jin Yang, Park, Myoung-Hwan
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 08-12-2016
Subjects:	Letter Micro-organogels near-infrared flurbiprofen gold nanorods on-demand drug delivery
Online Access:	Get full text
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Summary:	In this study, we designed a biocompatible drug carrier: micro-organogels prepared by emulsification using vegetable oils and self-assembled gelator fibers. Flurbiprofen was chosen as a hydrophobic model drug and is classified as a nonsteroidal anti-inflammatory drug. In the absence of NIR light, flurbiprofen encapsulated in micro-organogels with gold nanorods (GNRs) was released slowly, while release was accelerated in the presence of NIR light due to the increase in the temperature surrounding the GNRs that transforms the gels into liquid. These results suggest that our system can be efficiently used as a versatile scaffold for on-demand drug delivery systems.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1948-5875 1948-5875
DOI:	10.1021/acsmedchemlett.6b00293