Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes

Comparison of the secondary and three-dimensional structures of the hammerhead and pistol ribozymes reveals many close similarities, so in this work we have asked if they are mechanistically identical. We have determined a new crystal structure of the pistol ribozyme and have shown that G40 acts as...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 141; no. 19; pp. 7865 - 7875
Main Authors:	Wilson, Timothy J, Liu, Yijin, Li, Nan-Sheng, Dai, Qing, Piccirilli, Joseph A, Lilley, David M. J
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 15-05-2019
Subjects:	Catalytic Domain Guanine - metabolism Kinetics Models, Molecular Mutation Nucleic Acid Conformation RNA, Catalytic - chemistry RNA, Catalytic - genetics RNA, Catalytic - metabolism
Online Access:	Get full text
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