Evolution of Solid Phase Homochirality for a Proteinogenic Amino Acid

The inexorable evolution of solid-phase single chirality is demonstrated for the first time for a proteinogenic amino acid. Enantioenrichment is observed both under attrition-enhanced conditions and without the aid of particle grinding. Differences in the form of the conversion profiles for the proc...

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Bibliographic Details
Published in:	Journal of the American Chemical Society Vol. 130; no. 46; pp. 15274 - 15275
Main Authors:	Viedma, Cristobal, Ortiz, José E, Torres, Trinidad de, Izumi, Toshiko, Blackmond, Donna G
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 19-11-2008
Subjects:	Amino Acids - chemistry Molecular Structure Proteins - chemistry Stereoisomerism
Online Access:	Get full text
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Summary:	The inexorable evolution of solid-phase single chirality is demonstrated for the first time for a proteinogenic amino acid. Enantioenrichment is observed both under attrition-enhanced conditions and without the aid of particle grinding. Differences in the form of the conversion profiles for the process under the two sets of conditions provide suggestions concerning the mechanism of the transformation.
Bibliography:	ark:/67375/TPS-0VWDVNTQ-7 Details of experimental and analytical procedures. This material is available free of charge via the Internet at http://pubs.acs.org. istex:809A9A3A2FDB3ECB3D18AA1DED1263342F290402 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja8074506