Prenatal Diagnosis Innovation: Genome Sequencing of Maternal Plasma

Noninvasive prenatal testing (NIPT) is accomplished by analysis of circulating cell-free fetal nucleic acids in maternal plasma. The advent of massively parallel sequencing (MPS) has enabled NIPT of chromosomal aneuploidies with unprecedented robustness, and these tests are now widely available for...

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Bibliographic Details
Published in:	Annual review of medicine Vol. 67; no. 1; pp. 419 - 432
Main Authors:	Wong, Felix C.K, Lo, Y.M. Dennis
Format:	Journal Article
Language:	English
Published:	United States Annual Reviews 01-01-2016 Annual Reviews, Inc
Subjects:	Aneuploidy cell-free DNA Chromosomes DNA - blood DNA Methylation DNA Mutational Analysis Fetal Diseases - diagnosis Fetal Diseases - genetics Genetic disorders Genetic Testing - methods Genome, Human Genomes High-Throughput Nucleotide Sequencing Humans Innovations Maternal & child health Medical diagnosis methylome next-generation sequencing noninvasive prenatal testing Plasma Polymorphism, Single Nucleotide Prenatal development Prenatal Diagnosis - methods Transcriptome cell-free DNA methylome next-generation sequencing noninvasive prenatal testing transcriptome
Online Access:	Get full text
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