Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center

The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at a New York City medical center in 2011 as part of a routine surveillance program. Each isolate possessed a plasmid containing a pSCFS3-like cfr...

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Bibliographic Details
Published in:	Antimicrobial agents and chemotherapy Vol. 58; no. 11; pp. 6949 - 6952
Main Authors:	Locke, Jeffrey B, Zuill, Douglas E, Scharn, Caitlyn R, Deane, Jennifer, Sahm, Daniel F, Goering, Richard V, Jenkins, Stephen G, Shaw, Karen J
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01-11-2014
Subjects:	Acetamides Acetamides - pharmacology Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Bacterial Proteins Bacterial Proteins - genetics Clindamycin - pharmacology Diterpenes - pharmacology Drug Resistance, Multiple, Bacterial - genetics Gene Transfer Techniques Humans Linezolid Mechanisms of Resistance Methicillin-Resistant Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - isolation & purification Microbial Sensitivity Tests Molecular Sequence Data New York Organophosphates - pharmacology Oxazoles - pharmacology Oxazolidinones Oxazolidinones - pharmacology Plasmids - genetics Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus Thiamphenicol - analogs & derivatives Thiamphenicol - pharmacology New York
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Summary:	The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at a New York City medical center in 2011 as part of a routine surveillance program. Each isolate possessed a plasmid containing a pSCFS3-like cfr gene environment. Transformation of the cfr-bearing plasmids into the S. aureus ATCC 29213 background recapitulated the expected Cfr antibiogram, including resistance to linezolid, tiamulin, clindamycin, and florfenicol and susceptibility to tedizolid.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.03380-14