Benzothiopyranoindazoles, a new class of chromophore modified anthracenedione anticancer agents. Synthesis and activity against murine leukemias

The synthesis of the benzothiopyranoindazoles, a new class of chromophore modified anthracenediones related to mitoxantrone, is described. In this structural class the quinone moiety, which is believed to be responsible for the cardiotoxicity of the anthracyclines, has been designed out. The synthes...

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Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 31; no. 8; pp. 1527 - 1539
Main Authors:	Showalter, H. D. Hollis, Angelo, Mario M, Berman, Ellen M, Kanter, Gerald D, Ortwine, Daniel F, Ross-Kesten, Suzanne G, Sercel, Anthony D, Turner, William R, Werbel, Leslie M
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-08-1988
Subjects:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - therapeutic use Chemical Phenomena Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms In Vitro Techniques Indazoles - chemical synthesis Indazoles - pharmacology Indazoles - therapeutic use Leukemia L1210 - drug therapy Leukemia P388 - drug therapy Mice Organic chemistry Preparations and properties Pyrazoles - chemical synthesis Structure-Activity Relationship Antineoplastic agent Diamine Sulfur nitrogen heterocycle In vivo P388»-Leukemia Aromatic compound L1210-Leukemia Tetracyclic compound Biological activity
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