Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues

The trichodermamides are modified dipeptides isolated from a wide variety of fungi, including Trichoderma virens. Previous studies reported that trichodermamide B (2) initiated cytotoxicity in HCT-116 colorectal cancer cells, while trichodermamide A (1) was devoid of activity. We recently developed...

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Bibliographic Details
Published in:	Journal of natural products (Washington, D.C.) Vol. 80; no. 3; pp. 676 - 683
Main Authors:	Jans, Petra E, Mfuh, Adelphe M, Arman, Hadi D, Shaffer, Corena V, Larionov, Oleg V, Mooberry, Susan L
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society and American Society of Pharmacognosy 24-03-2017
Subjects:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Cell Cycle - drug effects Colorectal Neoplasms - drug therapy Dipeptides - chemical synthesis Dipeptides - chemistry Dipeptides - isolation & purification Dipeptides - pharmacology Diterpenes DNA - metabolism Fungi - drug effects HeLa Cells Humans Marine Biology Molecular Structure S Phase - drug effects Structure-Activity Relationship
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