Effect of Intestinal Flora on Protein Expression of Drug-Metabolizing Enzymes and Transporters in the Liver and Kidney of Germ-Free and Antibiotics-Treated Mice

Dysbiosis (alteration of intestinal flora) is associated with various host physiologies, including diseases. The purpose of this study was to clarify the effect of dysbiosis on protein expression levels in mouse liver and kidney by quantitative proteomic analysis, focusing in particular on drug-meta...

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Bibliographic Details

Published in:	Molecular pharmaceutics Vol. 13; no. 8; pp. 2691 - 2701
Main Authors:	Kuno, Takuya, Hirayama-Kurogi, Mio, Ito, Shingo, Ohtsuki, Sumio
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 01-08-2016
Subjects:	Animals Anti-Bacterial Agents Gastrointestinal Microbiome - drug effects Kidney - metabolism Liver - metabolism Male Mice Proteomics Specific Pathogen-Free Organisms targeted proteomics drug-metabolizing enzyme antibiotics quantitative proteomics transporter intestinal flora
Online Access:	Get full text
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