Novel Efficient Multistage Lead Optimization Pipeline Experimentally Validated for DYRK1B Selective Inhibitors

In addition to general challenges in drug discovery such as the identification of lead compounds in time- and cost-effective ways, specific challenges also exist. Particularly, it is necessary to develop pharmacological inhibitors that effectively discriminate between closely related molecular targe...

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Bibliographic Details

Published in:	Journal of medicinal chemistry Vol. 65; no. 20; pp. 13784 - 13792
Main Authors:	Alexandrov, Vadim, Vilenchik, Maria, Kantidze, Omar, Tsutskiridze, Nika, Kharchilava, Daviti, Lhewa, Pema, Shishkin, Aleksandr, Gankin, Yuriy, Kirpich, Alexander
Format:	Journal Article
Language:	English
Published:	American Chemical Society 27-10-2022
Online Access:	Get full text
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