Synthetic Approach toward Enantiopure Cyclic Sulfinamides

Synthetic Approach toward Enantiopure Cyclic Sulfinamides

A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective SN2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtained scaffold into chir...

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Bibliographic Details
Published in:Organic letters Vol. 24; no. 25; pp. 4625 - 4629
Main Authors: Jersovs, Glebs, Bojars, Matiss, Donets, Pavel A., Suna, Edgars
Format: Journal Article
Language:English
Published: American Chemical Society 01-07-2022
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Letter
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Summary:A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective SN2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtained scaffold into chiral SVI derivatives such as sulfoximines and sulfonimidamides is demonstrated.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c01738