Durability of Aligned Microtubules Dependent on Persistence Length Determines Phase Transition and Pattern Formation in Collective Motion
Collective motion is a ubiquitous phenomenon in nature. The collective motion of cytoskeleton filaments results mainly from dynamic collisions and alignments; however, the detailed mechanism of pattern formation still needs to be clarified. In particular, the influence of persistence length, which i...
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| Published in: | ACS nano Vol. 16; no. 9; pp. 14765 - 14778 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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27-09-2022
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| Abstract | Collective motion is a ubiquitous phenomenon in nature. The collective motion of cytoskeleton filaments results mainly from dynamic collisions and alignments; however, the detailed mechanism of pattern formation still needs to be clarified. In particular, the influence of persistence length, which is a measure of filament flexibility, on collective motion is still unclear and lacks experimental verifications although it is likely to directly affect the orientational flexibility of filaments. Here, we investigated the collective motion of microtubules with different persistence lengths using a microtubule–kinesin motility system. We showed that local interactions between microtubules significantly vary depending on their persistence length. We demonstrated that the bundling of microtubules is enhanced by more durable alignment, rather than by greater likelihood of alignment. An agent-based computational model confirmed that the rigidity-dependent durability of microtubule alignment dominates their collective behavior. |
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| AbstractList | Collective motion is a ubiquitous phenomenon in nature. The collective motion of cytoskeleton filaments results mainly from dynamic collisions and alignments; however, the detailed mechanism of pattern formation still needs to be clarified. In particular, the influence of persistence length, which is a measure of filament flexibility, on collective motion is still unclear and lacks experimental verifications although it is likely to directly affect the orientational flexibility of filaments. Here, we investigated the collective motion of microtubules with different persistence lengths using a microtubule–kinesin motility system. We showed that local interactions between microtubules significantly vary depending on their persistence length. We demonstrated that the bundling of microtubules is enhanced by more durable alignment, rather than by greater likelihood of alignment. An agent-based computational model confirmed that the rigidity-dependent durability of microtubule alignment dominates their collective behavior. |
| Author | Jung, Wonyeong Kim, Taeyoon Fujimoto, Kazuya Yokokawa, Ryuji Zhou, Hang Farhana, Tamanna Ishrat |
| AuthorAffiliation | Department of Micro Engineering Weldon School of Biomedical Engineering |
| AuthorAffiliation_xml | – name: Department of Micro Engineering – name: Weldon School of Biomedical Engineering |
| Author_xml | – sequence: 1 givenname: Hang orcidid: 0000-0003-0158-2244 surname: Zhou fullname: Zhou, Hang organization: Department of Micro Engineering – sequence: 2 givenname: Wonyeong surname: Jung fullname: Jung, Wonyeong organization: Weldon School of Biomedical Engineering – sequence: 3 givenname: Tamanna Ishrat orcidid: 0000-0001-8445-2642 surname: Farhana fullname: Farhana, Tamanna Ishrat organization: Department of Micro Engineering – sequence: 4 givenname: Kazuya surname: Fujimoto fullname: Fujimoto, Kazuya organization: Department of Micro Engineering – sequence: 5 givenname: Taeyoon orcidid: 0000-0002-5588-8532 surname: Kim fullname: Kim, Taeyoon organization: Weldon School of Biomedical Engineering – sequence: 6 givenname: Ryuji orcidid: 0000-0002-6306-2693 surname: Yokokawa fullname: Yokokawa, Ryuji email: yokokawa.ryuji.8c@kyoto-u.ac.jp organization: Department of Micro Engineering |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36098647$$D View this record in MEDLINE/PubMed |
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| Title | Durability of Aligned Microtubules Dependent on Persistence Length Determines Phase Transition and Pattern Formation in Collective Motion |
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