Differential GATA Factor Stabilities: Implications for Chromatin Occupancy by Structurally Similar Transcription Factors

Whereas the transcription factors GATA-1 and GATA-2 function both uniquely and redundantly to control blood cell development, the process termed hematopoiesis, mechanisms underlying their unique versus common functions are poorly understood. We used two independent assays to demonstrate that GATA-1...

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Bibliographic Details
Published in:	Biochemistry (Easton) Vol. 47; no. 3; pp. 859 - 869
Main Authors:	Lurie, Louis J, Boyer, Meghan E, Grass, Jeffrey A, Bresnick, Emery H
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 22-01-2008
Subjects:	Animals Cell Line, Tumor Cell Nucleus - metabolism Chromatin - metabolism Chromatin Immunoprecipitation Cycloheximide - pharmacology Cysteine Proteinase Inhibitors - pharmacology GATA1 Transcription Factor - genetics GATA1 Transcription Factor - metabolism GATA2 Transcription Factor - genetics GATA2 Transcription Factor - metabolism Gene Expression - drug effects Humans K562 Cells Leupeptins - pharmacology Mice Mutation - physiology Nuclear Proteins - genetics Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors Protein Biosynthesis - drug effects Protein Processing, Post-Translational - physiology Recombinant Fusion Proteins - metabolism Tamoxifen - pharmacology Transcription Factors - genetics Transcription Factors - metabolism Transfection
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