X‑ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case

The amantadine-resistant S31N mutant of the influenza A M2 proton channel has become prevalent in currently circulating viruses. Here, we have solved an X-ray crystal structure of M2(22–46) S31N that contains two distinct conformational states within its asymmetric unit. This structure reveals the m...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 141; no. 29; pp. 11481 - 11488
Main Authors:	Thomaston, Jessica L, Wu, Yibing, Polizzi, Nicholas, Liu, Lijun, Wang, Jun, DeGrado, William F
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 24-07-2019
Online Access:	Get full text
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