Distinctive Cognate Sequence Discrimination, Bound DNA Conformation, and Binding Modes in the E2 C-Terminal Domains from Prototype Human and Bovine Papillomaviruses

The C-terminal DNA binding domain of the E2 protein is involved in transcriptional regulation and DNA replication in papillomaviruses. At low ionic strength, the domain has a tendency to form aggregates, a process readily reversible by the addition of salt. While fluorescence anisotropy measurements...

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