Aporphines as antagonists of dopamine D-1 receptors

The aporphine alkaloids are a class of compounds known to possess activity at both D-1 and D-2 dopamine receptors. (R)-Apomorphine and (S)-bulbocapnine are examples of compounds which have agonist and antagonist activity, respectively, at D-1 receptors. A series of optically pure aporphines was synt...

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Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 33; no. 2; pp. 600 - 607
Main Authors:	Schaus, John M, Titus, Robert D, Foreman, Mark M, Mason, Norman R, Truex, Lewis L
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-02-1990
Subjects:	Adenylyl Cyclases - metabolism Animals aporphines Aporphines - pharmacology Benzazepines - metabolism Binding Sites Binding, Competitive Chemical Phenomena Chemistry Enzyme Activation - drug effects Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives In Vitro Techniques Organic chemistry Preparations and properties Rats Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Retina Spiperone - metabolism Structure-Activity Relationship Alkaloid Structure activity relation Nitrogen heterocycle D1 Dopamine receptor Aromatic compound Tetracyclic compound Agonist antagonist In vitro
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