Development of an Effective Scalable Enantioselective Synthesis of the HIV‑1 Entry Inhibitor BNM-III-170 as the Bis-trifluoroacetate Salt

We report here the development and optimization of a process synthesis for the human immunodeficiency virus-1 entry inhibitor BNM-III-170 bis-trifluoroacetate salt (1). The synthesis features a dynamic-kinetic resolution to establish the initial stereogenicity. By taking advantage of significant seq...

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Bibliographic Details

Published in:	Organic process research & development Vol. 23; no. 11; pp. 2464 - 2469
Main Authors:	Chen, Junhua, Park, Jun, Kirk, Sharon M, Chen, Hung-Ching, Li, Xiangqin, Lippincott, Daniel J, Melillo, Bruno, Smith, Amos B
Format:	Journal Article
Language:	English
Published:	American Chemical Society 15-11-2019
Subjects:	dynamic-kinetic resolution guanidine formation Gabriel amine synthesis CD4-mimetic HIV-1 entry inhibitor aminolysis
Online Access:	Get full text
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