Self-Collection Blood Test for PFASs: Comparing Volumetric Microsamplers with a Traditional Serum Approach

A remote sampling approach was developed at Eurofins for quantifying per- and polyfluoroalkyl substances (PFASs) in whole blood samples collected using volumetric absorptive microsamplers (VAMSs), which allow for self-collection of blood using a finger prick. This study compares PFAS exposure measur...

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Published in:	Environmental science & technology Vol. 57; no. 21; pp. 7950 - 7957
Main Authors:	Carignan, Courtney C., Bauer, Rachel A., Patterson, Andrew, Phomsopha, Thep, Redman, Eric, Stapleton, Heather M., Higgins, Christopher P.
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 30-05-2023
Subjects:	Absorptivity Blood Blood tests Capillary tubes Chromatography, Liquid Collection Contamination Drinking water Ecotoxicology and Public Health Fluorocarbons - analysis Hematologic Tests Humans Liquid chromatography Mass Spectrometry Mass spectroscopy Perfluoroalkyl & polyfluoroalkyl substances Solid phases Water pollution microsampling biomonitoring exposure Mitra serum PFAS blood
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Abstract	A remote sampling approach was developed at Eurofins for quantifying per- and polyfluoroalkyl substances (PFASs) in whole blood samples collected using volumetric absorptive microsamplers (VAMSs), which allow for self-collection of blood using a finger prick. This study compares PFAS exposure measured by self-collection of blood using VAMSs to the standard venous serum approach. Blood samples were collected from participants (n = 53) in a community with prior PFAS drinking water contamination using a venous blood draw as well as participant self-collection using VAMSs. Whole blood from the venous tubes was also loaded onto VAMSs to compare differences in capillary vs venous whole blood PFAS levels. Samples were quantified for PFASs using liquid chromatography tandem mass spectrometry and online solid-phase extraction. PFAS levels in serum were highly correlated with measurements in capillary VAMSs (r ≥ 0.91 and p < 0.05). Serum PFAS levels were generally twofold higher than whole blood, reflecting expected differences in their composition. Of interest, FOSA was detected in whole blood (both venous and capillary VAMSs) but not in serum. Overall, these findings indicate that VAMSs are useful self-collection tools for assessing elevated human exposure to PFASs.
AbstractList	A remote sampling approach was developed at Eurofins for quantifying per- and polyfluoroalkyl substances (PFASs) in whole blood samples collected using volumetric absorptive microsamplers (VAMSs), which allow for self-collection of blood using a finger prick. This study compares PFAS exposure measured by self-collection of blood using VAMSs to the standard venous serum approach. Blood samples were collected from participants (n = 53) in a community with prior PFAS drinking water contamination using a venous blood draw as well as participant self-collection using VAMSs. Whole blood from the venous tubes was also loaded onto VAMSs to compare differences in capillary vs venous whole blood PFAS levels. Samples were quantified for PFASs using liquid chromatography tandem mass spectrometry and online solid-phase extraction. PFAS levels in serum were highly correlated with measurements in capillary VAMSs (r ≥ 0.91 and p < 0.05). Serum PFAS levels were generally twofold higher than whole blood, reflecting expected differences in their composition. Of interest, FOSA was detected in whole blood (both venous and capillary VAMSs) but not in serum. Overall, these findings indicate that VAMSs are useful self-collection tools for assessing elevated human exposure to PFASs. A remote sampling approach was developed at Eurofins for quantifying per- and polyfluoroalkyl substances (PFASs) in whole blood samples collected using volumetric absorptive microsamplers (VAMSs), which allow for self-collection of blood using a finger prick. This study compares PFAS exposure measured by self-collection of blood using VAMSs to the standard venous serum approach. Blood samples were collected from participants ( = 53) in a community with prior PFAS drinking water contamination using a venous blood draw as well as participant self-collection using VAMSs. Whole blood from the venous tubes was also loaded onto VAMSs to compare differences in capillary vs venous whole blood PFAS levels. Samples were quantified for PFASs using liquid chromatography tandem mass spectrometry and online solid-phase extraction. PFAS levels in serum were highly correlated with measurements in capillary VAMSs ( ≥ 0.91 and < 0.05). Serum PFAS levels were generally twofold higher than whole blood, reflecting expected differences in their composition. Of interest, FOSA was detected in whole blood (both venous and capillary VAMSs) but not in serum. Overall, these findings indicate that VAMSs are useful self-collection tools for assessing elevated human exposure to PFASs. A remote sampling approach was developed at Eurofins for quantifying per- and polyfluoroalkyl substances (PFASs) in whole blood samples collected using volumetric absorptive microsamplers (VAMSs), which allow for self-collection of blood using a finger prick. This study compares PFAS exposure measured by self-collection of blood using VAMSs to the standard venous serum approach. Blood samples were collected from participants ( n = 53) in a community with prior PFAS drinking water contamination using a venous blood draw as well as participant self-collection using VAMSs. Whole blood from the venous tubes was also loaded onto VAMSs to compare differences in capillary vs venous whole blood PFAS levels. Samples were quantified for PFASs using liquid chromatography tandem mass spectrometry and online solid-phase extraction. PFAS levels in serum were highly correlated with measurements in capillary VAMSs ( r ≥ 0.91 and p < 0.05). Serum PFAS levels were generally twofold higher than whole blood, reflecting expected differences in their composition. Of interest, FOSA was detected in whole blood (both venous and capillary VAMSs) but not in serum. Overall, these findings indicate that VAMSs are useful self-collection tools for assessing elevated human exposure to PFASs. Volumetric absorptive microsamplers use capillary action to draw blood into the sampling device and can be a useful self-collection tool for measuring elevated PFAS in blood.
Author	Phomsopha, Thep Higgins, Christopher P. Stapleton, Heather M. Patterson, Andrew Redman, Eric Carignan, Courtney C. Bauer, Rachel A.
AuthorAffiliation	Department Food Science and Human Nutrition Eurofins Environment Testing America Nicholas School of the Environment Michigan State University Department of Civil & Environmental Engineering Department of Pharmacology and Toxicology
AuthorAffiliation_xml	– name: Michigan State University – name: Eurofins Environment Testing America – name: Department of Civil & Environmental Engineering – name: Nicholas School of the Environment – name: Department of Pharmacology and Toxicology – name: Department Food Science and Human Nutrition
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Snippet	A remote sampling approach was developed at Eurofins for quantifying per- and polyfluoroalkyl substances (PFASs) in whole blood samples collected using... A remote sampling approach was developed at Eurofins for quantifying per- and polyfluoroalkyl substances (PFASs) in whole blood samples collected using...
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SubjectTerms	Absorptivity Blood Blood tests Capillary tubes Chromatography, Liquid Collection Contamination Drinking water Ecotoxicology and Public Health Fluorocarbons - analysis Hematologic Tests Humans Liquid chromatography Mass Spectrometry Mass spectroscopy Perfluoroalkyl & polyfluoroalkyl substances Solid phases Water pollution
Title	Self-Collection Blood Test for PFASs: Comparing Volumetric Microsamplers with a Traditional Serum Approach
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