Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer’s Disease Across Distinct Brain Regions

Alzheimer’s disease (AD) is a neurodegenerative disease with a complex etiology influenced by confounding factors such as genetic polymorphisms, age, sex, and race. Traditionally, AD research has not prioritized these influences, resulting in dramatically skewed cohorts such as three times the numbe...

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Bibliographic Details
Published in:	Journal of proteome research Vol. 23; no. 8; pp. 2970 - 2985
Main Authors:	Odenkirk, Melanie T., Zheng, Xueyun, Kyle, Jennifer E., Stratton, Kelly G., Nicora, Carrie D., Bloodsworth, Kent J., Mclean, Catriona A., Masters, Colin L., Monroe, Matthew E., Doecke, James D., Smith, Richard D., Burnum-Johnson, Kristin E., Roberts, Blaine R., Baker, Erin S.
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 02-08-2024
Subjects:	Aged Aged, 80 and over Alleles Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Apolipoprotein E4 - genetics Apolipoproteins E - genetics Brain - metabolism Brain - pathology Cerebellum - metabolism Cerebellum - pathology Female Frontal Lobe - metabolism Frontal Lobe - pathology Genotype Humans Lipidomics Male Proteomics - methods Alzheimer’s disease proteomics apolipoprotein E (APOE) lipidomics
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