Basal ganglia pathology in schizophrenia and tardive dyskinesia: an MRI quantitative study

Magnetic resonance imaging was used to measure the volumes of the caudate, putamen, and globus pallidus of 25 schizophrenic patients (17 men and eight women) and 26 age- and sex-matched comparison subjects (18 men and eight women). Schizophrenic patients had significantly larger right and left globu...

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Bibliographic Details
Published in:	The American journal of psychiatry Vol. 151; no. 5; p. 752
Main Authors:	Elkashef, A M, Buchanan, R W, Gellad, F, Munson, R C, Breier, A
Format:	Journal Article
Language:	English
Published:	United States 01-05-1994
Subjects:	Adult Antipsychotic Agents - adverse effects Basal Ganglia - anatomy & histology Basal Ganglia - pathology Caudate Nucleus - anatomy & histology Caudate Nucleus - pathology Dyskinesia, Drug-Induced - diagnosis Dyskinesia, Drug-Induced - etiology Dyskinesia, Drug-Induced - pathology Female Functional Laterality Globus Pallidus - anatomy & histology Globus Pallidus - pathology Humans Hypertrophy - pathology Magnetic Resonance Imaging Male Schizophrenia - diagnosis Schizophrenia - drug therapy Schizophrenia - pathology
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Summary:	Magnetic resonance imaging was used to measure the volumes of the caudate, putamen, and globus pallidus of 25 schizophrenic patients (17 men and eight women) and 26 age- and sex-matched comparison subjects (18 men and eight women). Schizophrenic patients had significantly larger right and left globus pallidus and right putamen volumes than comparison subjects. There were no significant differences between schizophrenic patients with and without persistent tardive dyskinesia in the volume of any of the three structures.
ISSN:	0002-953X
DOI:	10.1176/ajp.151.5.752