Unveiling in Vivo Subcutaneous Thermal Dynamics by Infrared Luminescent Nanothermometers

The recent development of core/shell engineering of rare earth doped luminescent nanoparticles has ushered a new era in fluorescence thermal biosensing, allowing for the performance of minimally invasive experiments, not only in living cells but also in more challenging small animal models. Here, th...

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Published in:	Nano letters Vol. 16; no. 3; pp. 1695 - 1703
Main Authors:	Ximendes, Erving Clayton, Santos, Weslley Queiroz, Rocha, Uéslen, Kagola, Upendra Kumar, Sanz-Rodríguez, Francisco, Fernández, Nuria, Gouveia-Neto, Artur da Silva, Bravo, David, Domingo, Agustín Martín, del Rosal, Blanca, Brites, Carlos D. S, Carlos, Luís Dias, Jaque, Daniel, Jacinto, Carlos
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 09-03-2016
Subjects:	Administration, Cutaneous Animals Biological Body Temperature Detection Infrared Infrared Rays Luminescence Luminescent Measurements - instrumentation Mice Monitoring Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanostructure Neodymium - administration & dosage Neodymium - chemistry Rare earth metals Skin Physiological Phenomena Thermometers Ytterbium - administration & dosage Ytterbium - chemistry Nanothermometry rare earth nanoparticles second biological window subcutaneous thermal sensing
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Abstract	The recent development of core/shell engineering of rare earth doped luminescent nanoparticles has ushered a new era in fluorescence thermal biosensing, allowing for the performance of minimally invasive experiments, not only in living cells but also in more challenging small animal models. Here, the potential use of active-core/active-shell Nd3+- and Yb3+-doped nanoparticles as subcutaneous thermal probes has been evaluated. These temperature nanoprobes operate in the infrared transparency window of biological tissues, enabling deep temperature sensing into animal bodies thanks to the temperature dependence of their emission spectra that leads to a ratiometric temperature readout. The ability of active-core/active-shell Nd3+- and Yb3+-doped nanoparticles for unveiling fundamental tissue properties in in vivo conditions was demonstrated by subcutaneous thermal relaxation monitoring through the injected core/shell nanoparticles. The reported results evidence the potential of infrared luminescence nanothermometry as a diagnosis tool at the small animal level.
AbstractList	The recent development of core/shell engineering of rare earth doped luminescent nanoparticles has ushered a new era in fluorescence thermal biosensing, allowing for the performance of minimally invasive experiments, not only in living cells but also in more challenging small animal models. Here, the potential use of active-core/active-shell Nd super(3+)- and Yb super(3+)-doped nanoparticles as subcutaneous thermal probes has been evaluated. These temperature nanoprobes operate in the infrared transparency window of biological tissues, enabling deep temperature sensing into animal bodies thanks to the temperature dependence of their emission spectra that leads to a ratiometric temperature readout. The ability of active-core/active-shell Nd super(3+)- and Yb super(3+)-doped nanoparticles for unveiling fundamental tissue properties in in vivo conditions was demonstrated by subcutaneous thermal relaxation monitoring through the injected core/shell nanoparticles. The reported results evidence the potential of infrared luminescence nanothermometry as a diagnosis tool at the small animal level. Keywords: Nanothermometry; rare earth nanoparticles; second biological window; subcutaneous thermal sensing The recent development of core/shell engineering of rare earth doped luminescent nanoparticles has ushered a new era in fluorescence thermal biosensing, allowing for the performance of minimally invasive experiments, not only in living cells but also in more challenging small animal models. Here, the potential use of active-core/active-shell Nd(3+)- and Yb(3+)-doped nanoparticles as subcutaneous thermal probes has been evaluated. These temperature nanoprobes operate in the infrared transparency window of biological tissues, enabling deep temperature sensing into animal bodies thanks to the temperature dependence of their emission spectra that leads to a ratiometric temperature readout. The ability of active-core/active-shell Nd(3+)- and Yb(3+)-doped nanoparticles for unveiling fundamental tissue properties in in vivo conditions was demonstrated by subcutaneous thermal relaxation monitoring through the injected core/shell nanoparticles. The reported results evidence the potential of infrared luminescence nanothermometry as a diagnosis tool at the small animal level. The recent development of core/shell engineering of rare earth doped luminescent nanoparticles has ushered a new era in fluorescence thermal biosensing, allowing for the performance of minimally invasive experiments, not only in living cells but also in more challenging small animal models. Here, the potential use of active-core/active-shell Nd3+- and Yb3+-doped nanoparticles as subcutaneous thermal probes has been evaluated. These temperature nanoprobes operate in the infrared transparency window of biological tissues, enabling deep temperature sensing into animal bodies thanks to the temperature dependence of their emission spectra that leads to a ratiometric temperature readout. The ability of active-core/active-shell Nd3+- and Yb3+-doped nanoparticles for unveiling fundamental tissue properties in in vivo conditions was demonstrated by subcutaneous thermal relaxation monitoring through the injected core/shell nanoparticles. The reported results evidence the potential of infrared luminescence nanothermometry as a diagnosis tool at the small animal level.
Author	Ximendes, Erving Clayton Rocha, Uéslen Bravo, David Domingo, Agustín Martín Brites, Carlos D. S Carlos, Luís Dias del Rosal, Blanca Jacinto, Carlos Fernández, Nuria Santos, Weslley Queiroz Sanz-Rodríguez, Francisco Kagola, Upendra Kumar Gouveia-Neto, Artur da Silva Jaque, Daniel
AuthorAffiliation	Grupo de Fotônica e Fluidos Complexos, Instituto de Física University of Aveiro Universidade Federal de Alagoas Departamento de Física and CICECOAveiro Institute of Materials Fluorescence Imaging Group, Departamento de Física de Materiales, Faculdad de Ciencias Universidad Autónoma de Madrid
AuthorAffiliation_xml	– name: Universidad Autónoma de Madrid – name: Grupo de Fotônica e Fluidos Complexos, Instituto de Física – name: Universidade Federal de Alagoas – name: Departamento de Física and CICECOAveiro Institute of Materials – name: Fluorescence Imaging Group, Departamento de Física de Materiales, Faculdad de Ciencias – name: University of Aveiro
Author_xml	– sequence: 1 givenname: Erving Clayton surname: Ximendes fullname: Ximendes, Erving Clayton – sequence: 2 givenname: Weslley Queiroz surname: Santos fullname: Santos, Weslley Queiroz – sequence: 3 givenname: Uéslen surname: Rocha fullname: Rocha, Uéslen – sequence: 4 givenname: Upendra Kumar surname: Kagola fullname: Kagola, Upendra Kumar – sequence: 5 givenname: Francisco surname: Sanz-Rodríguez fullname: Sanz-Rodríguez, Francisco – sequence: 6 givenname: Nuria surname: Fernández fullname: Fernández, Nuria – sequence: 7 givenname: Artur da Silva surname: Gouveia-Neto fullname: Gouveia-Neto, Artur da Silva – sequence: 8 givenname: David surname: Bravo fullname: Bravo, David – sequence: 9 givenname: Agustín Martín surname: Domingo fullname: Domingo, Agustín Martín – sequence: 10 givenname: Blanca surname: del Rosal fullname: del Rosal, Blanca – sequence: 11 givenname: Carlos D. S surname: Brites fullname: Brites, Carlos D. S – sequence: 12 givenname: Luís Dias surname: Carlos fullname: Carlos, Luís Dias – sequence: 13 givenname: Daniel surname: Jaque fullname: Jaque, Daniel email: daniel.jaque@uam.es – sequence: 14 givenname: Carlos surname: Jacinto fullname: Jacinto, Carlos email: cjacinto@fis.ufal.br
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26845418$$D View this record in MEDLINE/PubMed
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Snippet	The recent development of core/shell engineering of rare earth doped luminescent nanoparticles has ushered a new era in fluorescence thermal biosensing,...
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SubjectTerms	Administration, Cutaneous Animals Biological Body Temperature Detection Infrared Infrared Rays Luminescence Luminescent Measurements - instrumentation Mice Monitoring Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanostructure Neodymium - administration & dosage Neodymium - chemistry Rare earth metals Skin Physiological Phenomena Thermometers Ytterbium - administration & dosage Ytterbium - chemistry
Title	Unveiling in Vivo Subcutaneous Thermal Dynamics by Infrared Luminescent Nanothermometers
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