Cytotoxicities of Some Flavonoid Analogues

• Published in: Journal of natural products (Washington, D.C.) Vol. 54; no. 6; pp. 1656 - 1660
• Main Authors: Cushman, Mark, Nagarathnam, Dhanapalan
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01-11-1991; Glendale, AZ American Society of Pharmacognosy
• Subjects: adenoma; adenome; agentes antineoplasticos; Antineoplastic agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological and medical sciences; carcinoma; carcinome; cell culture; cultivo de celulas; culture de cellule; Drug Screening Assays, Antitumor; flavonoide; flavonoides; flavonoids; Flavonoids - chemistry; Flavonoids - pharmacology; General aspects; Medical sciences; medicament cytostatique; melanoma; melanome; Pharmacology. Drug treatments; Structure-Activity Relationship; substance toxique; sustancias toxicas; toxic substances; toxicidad; toxicite; toxicity; Tumor Cells, Cultured; Antineoplastic agent; Synthetic product; Analog; Flavonoid; In vitro; Biological activity; Tumor cell
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np50078a027

An array of 55 flavones having a variety of substituents was evaluated for cytotoxicity in five cancer cell cultures: A-549 lung carcinoma, MCF-7 breast carcinoma, HT-29 colon adenocarcinoma, SKMEL-5 melanoma, and MLM melanoma. Fifteen of the 55 flavone derivatives were significantly active against at least one of these cell cultures, and 4'-[(t-butyldi-methylsily)oxy]-7,8-dihydroxy-3',5'- dimethoxyflavone [40] was the most active of all. Structure-activity relationships of these compounds are discussed.