Synthesis of Lipid-Linked Arabinofuranose Donors for Glycosyltransferases

Mycobacteria and corynebacteria use decaprenylphosphoryl-β-d-arabinofuranose (DPA) as a critical cell wall building block. Arabinofuranosyltransferases that process this substrate to mediate cell wall assembly have served as drug targets, but little is known about the substrate specificity of any of...

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Bibliographic Details

Published in:	Journal of organic chemistry Vol. 78; no. 5; pp. 2128 - 2133
Main Authors:	Kraft, Matthew B, Martinez Farias, Mario A, Kiessling, Laura L
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 01-03-2013
Subjects:	Arabinose - analogs & derivatives Arabinose - chemical synthesis Arabinose - chemistry Cell Wall - chemistry Cell Wall - metabolism Glycolipids - chemistry Glycosyltransferases - chemistry Glycosyltransferases - metabolism Lipids - chemistry Molecular Structure Mycobacterium - chemistry Polyisoprenyl Phosphates - chemistry Stereoisomerism Substrate Specificity
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