Synthesis and Characterization of Oligonucleotides Containing a Nitrogen Mustard Formamidopyrimidine Monoadduct of Deoxyguanosine

N 5-Substituted formamidopyrimidine adducts have been observed from the reaction of dGuo or DNA with aziridine containing electrophiles, including nitrogen mustards. However, the role of substituted Fapy-dGuo adducts in the biological response to nitrogen mustards and related species has not been ex...

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Bibliographic Details
Published in:	Chemical research in toxicology Vol. 27; no. 9; pp. 1610 - 1618
Main Authors:	Christov, Plamen P, Son, Kyu-Jun, Rizzo, Carmelo J
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 15-09-2014
Subjects:	Base Sequence Deoxyguanosine - chemistry Deoxyribonuclease IV (Phage T4-Induced) - metabolism DNA Adducts - chemistry DNA Repair DNA-Formamidopyrimidine Glycosylase - metabolism Electrophoresis, Agar Gel Escherichia coli - enzymology Escherichia coli Proteins - metabolism Kinetics Mechlorethamine - chemistry Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Organophosphorus Compounds - chemical synthesis Organophosphorus Compounds - chemistry Pyrimidines - chemistry
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