Metabolic Engineering of Saccharomyces cerevisiae To Overproduce Squalene

Squalene has wide applications in the food and pharmaceutical industries. Engineering microbes to produce squalene is a promising alternative for traditional production approaches. In this study, squalene production was enhanced to 978.24 mg/L through stepwise overexpression of the enzymes that cata...

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Bibliographic Details
Published in:	Journal of agricultural and food chemistry Vol. 68; no. 7; pp. 2132 - 2138
Main Authors:	Li, Tian, Liu, Guo-Song, Zhou, Wei, Jiang, Min, Ren, Yu-Hong, Tao, Xin-Yi, Liu, Min, Zhao, Ming, Wang, Feng-Qing, Gao, Bei, Wei, Dong-Zhi
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 19-02-2020
Subjects:	Acetyl Coenzyme A - metabolism Ethanol - metabolism Fermentation Metabolic Engineering NADP - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Squalene - metabolism carbon source utilization metabolic engineering Saccharomyces cerevisiae squalene ethanol overproduction
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