No fitness cost entailed by type VI secretion system synthesis, assembly, contraction, or disassembly in enteroaggregative Escherichia coli

Bacteria use weapons to deliver effectors into target cells. One of these weapons, the type VI secretion system (T6SS), assembles a contractile tail acting as a spring to propel a toxin-loaded needle. Due to its size and mechanism of action, the T6SS was intuitively thought to be energetically costl...

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Bibliographic Details
Published in:	Journal of bacteriology Vol. 205; no. 12; p. e0035723
Main Authors:	Taillefer, Boris, Giraud, Julien F, Cascales, Eric
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 19-12-2023
Subjects:	Bacterial Proteins Bacteriology Conformation Contractility Cytoplasm Dismantling E coli Escherichia coli Escherichia coli - genetics Escherichia coli Proteins - genetics Gram-positive bacteria Life Sciences Research Article Secretion Sheaths Synthesis Type VI Secretion Systems - genetics protein transport toxin delivery cost bacterial competition contraction growth secretion system ATP energy
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Summary:	Bacteria use weapons to deliver effectors into target cells. One of these weapons, the type VI secretion system (T6SS), assembles a contractile tail acting as a spring to propel a toxin-loaded needle. Due to its size and mechanism of action, the T6SS was intuitively thought to be energetically costly. Here, using a combination of mutants and growth measurements in liquid medium, on plates, and in competition experiments, we show that the T6SS does not entail a growth cost to enteroaggregative .
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The authors declare no conflict of interest.
ISSN:	0021-9193 1098-5530 1098-5530
DOI:	10.1128/jb.00357-23