Addison Disease and Normocalcemic Primary Hyperparathyroidism in a Dog with Multiple Endocrine Neoplasia

• Published in: Open veterinary journal (Tripoli, Libya) Vol. 7; no. 4; pp. 332 - 336
• Main Authors: Castillo , Victor Alejandro, Arias , Elber Alberto Soler, Trigo , Roberto Hector
• Format: Journal Article
• Language: English
• Published: Tripoli, Libya University of Tripoli : Faculty of Veterinary Medicine 01-01-2017; Faculty of Veterinary Medicine, University of Tripoli and Libyan Authority for Research, Science and Technology; Tripoli University
• Subjects: ADRENAL GLANDS; Case Report; DOGS; ENDOCRINE DISEASES; HYPERPARATHYROIDISM; Hypoadrenocorticism; PARATHYROID ADENOMA; Pheochromocytoma; PHEOCHROMOCYTOMS; Synaptophysin; أمراض الغدد الصماء; الغدد الكظرية; الكلاب; الورم الغدي الدريقي; فرط الدريقية; ورم الخلايا الصبغية
• ISSN: 2226-4485; 2218-6050; 2218-6050
• DOI: 10.4314/ovj.v7i4.8

A 12-year old dog with a 9-year history of primary adrenal insufficiency was referred to the service for hyporexia, muscle weakness, polyuria and polydipsia. Ultrasound examination showed an unresectable mass in the left adrenal gland, with local vascular invasion, which prompted the euthanasia of the animal. Additionally, necropsy revealed a nodular lesion in the right adrenal gland and enlargement of one of the four parathyroid glands. Parathyroid hormone levels were elevated, but ionized and total calcium levels were normal. Histopathology supported the diagnosis of parathyroid chief cell adenoma and bilateral pheochromocytoma. Immunohistochemical staining was positive for synaptophysin, and negative for Melan-A and calretinin, which confirmed the diagnosis of pheochromocytoma. This case highlights an unusual presentation of multiple endocrine neoplasias within the context of primary adrenal insufficiency and normocalcemic primary hyperparathyroidism.