New Steroidal 4‑Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model

The synthesis and inhibitory potencies against botulinum neurotoxin serotype A light chain (BoNT/A LC) using in vitro HPLC based enzymatic assay for various steroidal, benzothiophene, thiophene, and adamantane 4-aminoquinoline derivatives are described. In addition, the compounds were evaluated for...

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Bibliographic Details

Published in:	Journal of medicinal chemistry Vol. 61; no. 4; pp. 1595 - 1608
Main Authors:	Konstantinović, Jelena, Kiris, Erkan, Kota, Krishna P, Kugelman-Tonos, Johanny, Videnović, Milica, Cazares, Lisa H, Terzić Jovanović, Nataša, Verbić, Tatjana Ž, Andjelković, Boban, Duplantier, Allen J, Bavari, Sina, Šolaja, Bogdan A
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 22-02-2018
Online Access:	Get full text
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