Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid and Mild Way to Access Functionalized Orthoesters

Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid and Mild Way to Access Functionalized Orthoesters

A new electrochemical methodology has been developed for the preparation of a wide variety of functionalized orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri­(fluorinated) orthoesters, a class...

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Bibliographic Details
Published in:Organic letters Vol. 22; no. 10; pp. 4000 - 4005
Main Authors: Garcia, Anthony D, Leech, Matthew C, Petti, Alessia, Denis, Camille, Goodall, Iain C. A, Dobbs, Adrian P, Lam, Kevin
Format: Journal Article
Language:English
Published: United States American Chemical Society 15-05-2020
Online Access:Get full text
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Summary:A new electrochemical methodology has been developed for the preparation of a wide variety of functionalized orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri­(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalized orthoesters from simple and readily available starting materials.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c01324