Asterixis (Flapping Tremors) As an Outcome of Complex Psychotropic Drug Interaction

A study on 10 patients, most with affective spectrum disorders being treated with combination therapy where the drugs most often used were clozapine (eight cases), lithium (seven cases), and carbamazepine (seven cases); but there were neither metabolic disorders nor structural brain lesions that cou...

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Bibliographic Details
Published in:	The journal of neuropsychiatry and clinical neurosciences Vol. 24; no. 1; pp. E26 - E27
Main Authors:	Nayak, Raghavendra, Pandurangi, Aditya, Bhogale, Govind, Patil, Nanasaheb, Chate, Sameeran
Format:	Journal Article
Language:	English
Published:	United States American Psychiatric Publishing, Inc 2012
Subjects:	Antipsychotic Agents - adverse effects Cataplexy - chemically induced Clozapine - adverse effects Drug dosages Drug therapy Female Humans Metabolic disorders Psychotropic drugs
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Summary:	A study on 10 patients, most with affective spectrum disorders being treated with combination therapy where the drugs most often used were clozapine (eight cases), lithium (seven cases), and carbamazepine (seven cases); but there were neither metabolic disorders nor structural brain lesions that could explain the occurrence of asterixis. Asterixis seems to be due to a central effect of the drug unrelated to hepatotoxicity or sedation.5 The most common side effect of sodium valproate is dose-related tremor, occurring in as many as one-quarter of chronically treated patients.
ISSN:	0895-0172 1545-7222
DOI:	10.1176/appi.neuropsych.10110266