In Vitro Antiviral Activity of Dammar Resin Triterpenoids

• Published in: Journal of natural products (Washington, D.C.) Vol. 50; no. 4; pp. 706 - 713
• Main Authors: Poehland, B. L, Carté, B. K, Francis, T. A, Hyland, L. J, Allaudeen, H. S, Troupe, N
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01-07-1987; Glendale, AZ American Society of Pharmacognosy
• Subjects: ANTIVIRAL; ANTIVIRAL AGENTS; Biological and medical sciences; BURSERACEAE; DIPTEROCARPACEAE; General pharmacology; HIDROCARBUROS; HYDROCARBONS; HYDROCARBURE; Magnetic Resonance Spectroscopy; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants, Medicinal - analysis; RESINAS; RESINE; RESINS; Resins, Plant - analysis; Simplexvirus - drug effects; Triterpenes - isolation & purification; Triterpenes - pharmacology; VIRICIDAS; Virus; Herpesvirus hominis 1; Herpesviridae; Alphaherpesvirinae; Triterpene; Antiviral; Resins; In vitro; Biological activity
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np50052a022

Nine triterpenes with antiviral activity against Herpes simplex virus types I and II in vitro were isolated from dammar resin. Each compound caused a significant reduction in viral cytopathic effect when Vero cells were exposed continuously to 1-10 micrograms/ml of compound for 48 h after viral challenge. The triterpenes were identified as dammaradienol [1], dammarenediol-II [2], hydroxydammarenone-I [3], ursonic acid [5], hydroxyhopanone [11], dammarenolic acid [15], shoreic acid [16], eichlerianic acid [17], and a novel compound, hydroxyoleanonic lactone [7], on the basis of their chromatographic, spectroscopic, and physical properties.