Chemistry and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile

Despite their discovery in the early 20th century and intensive study over the last 20 years, nicotinic acetylcholine receptors (nAChRs) are still far from being well understood. Only a few chemical entities targeting nAChRs are currently undergoing clinical trials, and even fewer have reached the m...

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Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 55; no. 2; pp. 717 - 724
Main Authors:	Zhang, Hankun, Tückmantel, Werner, Eaton, J. Brek, Yuen, Po-wai, Yu, Li-Fang, Bajjuri, Krishna Mohan, Fedolak, Allison, Wang, Daguang, Ghavami, Afshin, Caldarone, Barbara, Paterson, Neil E, Lowe, David A, Brunner, Daniela, Lukas, Ronald J, Kozikowski, Alan P
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 26-01-2012
Subjects:	Animals Antidepressive Agents - chemical synthesis Antidepressive Agents - chemistry Antidepressive Agents - pharmacology Behavior, Animal - drug effects Cell Line Crystallography, X-Ray Drug Partial Agonism Female Humans Ligands Mice Mice, Inbred BALB C Molecular Conformation Nicotinic Agonists - chemical synthesis Nicotinic Agonists - chemistry Nicotinic Agonists - pharmacology Radioligand Assay Rats Receptors, Nicotinic - metabolism Stereoisomerism Structure-Activity Relationship
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