Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity

The synthesis, biological evaluation, and structure-activity relationships of a series of 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols are described. These compounds show potent dose-dependent topical antiinflammatory activity in murine models of skin inflammation. This effect is likely due to in...

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Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 35; no. 17; pp. 3148 - 3155
Main Authors:	Wright, Stephen W, Harris, Richard R, Collins, Robert J, Corbett, Ronald L, Green, Alicia M, Wadman, Eric A, Batt, Douglas G
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-08-1992
Subjects:	Administration, Topical Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Arachidonic Acid Calcimycin Chemistry Cyclooxygenase Inhibitors - pharmacology Dermatitis - drug therapy Dermatitis - etiology Edema - chemically induced Edema - drug therapy Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Imidazoles - chemical synthesis Imidazoles - pharmacology Imidazoles - therapeutic use Lipoxygenase Inhibitors - pharmacology Male Mice Molecular Structure Organic chemistry Phospholipases A - antagonists & inhibitors Preparations and properties Pyridines - chemical synthesis Pyridines - pharmacology Pyridines - therapeutic use Structure-Activity Relationship Tetradecanoylphorbol Acetate Non steroidal antiinflammatory agent In vivo Five membered ring Nitrogen heterocycle Tertiary alcohol Six membered ring Fluorine Organic compounds Biological activity
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