Synthesis and biological activity of novel quaternary ammonium derivatives of alkylglycerols as potent inhibitors of protein kinase C

Alkylglycerols such as rac-1-O-octadecyl-2-O-methylglycerophosphochocholine (Et-18-OMe) have shown an inhibitory effect on the metastasis and growth of various cancer cell lines. Alkyl phospholipids have been shown to accumulate at the surface in several cell lines, the selectivity of which is still...

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Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 33; no. 3; pp. 985 - 992
Main Authors:	Marasco, Canio J, Piantadosi, Claude, Meyer, Karen L, Morris-Natschke, Susan, Ishaq, Khalid S, Small, George W, Daniel, Larry W
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-03-1990
Subjects:	Aliphatic compounds alkylglycerols ammonium Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Chemistry Diglycerides - pharmacology Exact sciences and technology Humans Organic chemistry Phosphatidylserines - pharmacology Phospholipid Ethers - chemical synthesis Phospholipid Ethers - pharmacology Preparations and properties Protein Kinase C - antagonists & inhibitors Structure-Activity Relationship Antineoplastic agent Protein kinase C Organic cation Ether Aliphatic compound Saturated compound Enzyme inhibitor Biological activity Organic sulfide
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