Trichomycins A and B:  Antibacterial Triterpenes from the New Species Tricholoma sp. AU1

• Published in: Journal of natural products (Washington, D.C.) Vol. 68; no. 3; pp. 409 - 412
• Main Authors: Ovenden, Simon P. B, Yu, Jin, Bernays, Jill, Wan, Soo San, Christophidis, Larissa J, Sberna, Gian, Tait, R. Murray, Wildman, Howard G, Lebeller, Dominique, Platel, Denis, May, Tom W, Meurer-Grimes, Barbara M
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 24-03-2005; Glendale, AZ American Society of Pharmacognosy
• Subjects: antibacterial properties; Biological and medical sciences; chemical structure; General pharmacology; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; secondary metabolites; spectral analysis; stereochemistry; Tricholoma; trichomycins; triterpenoids; Victoria (Australia); Antineoplastic agent; Relative configuration; Leukemia; Saturated compound; Basidiomycetes; Cytotoxicity; Medicinal plant; Fungi; Carboxylic acid; Gram positive bacteria; Tertiary alcohol; Bicyclic compound; Secondary alcohol; Tumor cell; Monocyclic compound; Thallophyta; Gram negative bacteria; Terpenoid; Pharmacognosy; Tricholoma; In vitro; Naphthalene derivatives; Biological activity; Cell line; Triterpene; Isolation; Antibacterial agent; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np049747j

To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their antibacterial activity. The two compounds were found to have a hitherto unreported triterpenoid skeleton. The structures and relative stereochemistry of 1 and 2 were determined through extensive 2D NMR spectroscopy, while the inhibitory activity of 1 and 2 against two Gram-positive and two Gram-negative bacteria and a mammalian cell line was determined.