Stability and Comparative Metabolism of Selected Felbamate Metabolites and Postulated Fluorofelbamate Metabolites by Postmitochondrial Suspensions

Evidence has been presented suggesting that a reactive metabolite, 2-phenylpropenal (ATPAL), may be responsible for the toxicities observed during therapy with the antiepileptic drug felbamate (FBM). Formation of ATPAL from its unstable immediate precursor, 3-carbamoyl-2-phenylpropionaldedhyde (CBMA...

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Bibliographic Details
Published in:	Chemical research in toxicology Vol. 18; no. 12; pp. 1842 - 1848
Main Authors:	Parker, Robert J, Hartman, Neil R, Roecklein, Bryan A, Mortko, Henry, Kupferberg, Harvey J, Stables, James, Strong, John M
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 01-12-2005
Subjects:	Aldehydes - chemistry Anticonvulsants - chemistry Aza Compounds - chemistry Aza Compounds - metabolism Cells, Cultured Fluorine - chemistry Fluorine - metabolism Humans Mass Spectrometry Mitochondria, Liver - chemistry Mitochondria, Liver - metabolism NAD - chemistry Oxazines Oxidation-Reduction Phenylcarbamates Propylene Glycols - chemistry Propylene Glycols - metabolism Signal Transduction
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