Bioceramics Composed of Octacalcium Phosphate Demonstrate Enhanced Biological Behavior

• Published in: ACS applied materials & interfaces Vol. 6; no. 19; pp. 16610 - 16620
• Main Authors: Komlev, Vladimir S, Barinov, Sergei M, Bozo, Ilya I, Deev, Roman V, Eremin, Ilya I, Fedotov, Alexander Yu, Gurin, Alex N, Khromova, Natalia V, Kopnin, Pavel B, Kuvshinova, Ekaterina A, Mamonov, Vasily E, Rybko, Vera A, Sergeeva, Natalia S, Teterina, Anastasia Yu, Zorin, Vadim L
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08-10-2014
• Subjects: Adult; Animals; Biopsy; Bone and Bones - pathology; Calcium Carbonate - pharmacology; Calcium Phosphates - pharmacology; Cattle; Ceramics - pharmacology; Female; Humans; Kidney - drug effects; Male; Mice; Middle Aged; Osteocalcin - metabolism; Osteogenesis - drug effects; Rats, Wistar; Serum Albumin, Bovine - metabolism; Spectrophotometry, Infrared; X-Ray Diffraction; ceramics; osteoconductive; osteotransductive features; bone graft; octacalcium phosphate; osteoinductive
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/am502583p

Bioceramics are used to treat bone defects but in general do not induce formation of new bone, which is essential for regeneration process. Many aspects related to bioceramics synthesis, properties and biological response that are still unknown and, there is a great need for further development. In the most recent research efforts were aimed on creation of materials from biological precursors of apatite formation in humans. One possible precursor is octacalcium phosphate (OCP), which is believed to not only exhibit osteoconductivity but possess osteoinductive quality, the ability to induce bone formation. Here we propose a relatively simple route for OCP ceramics preparation with a specifically designed microstructure. Comprehensive study for OCP ceramics including biodegradation, osteogenic properties in ortopic and heterotopic models and limited clinical trials were performed that demonstrated enhanced biological behavior. Our results provide a possible new concept for the clinical applications of OCP ceramics.