Toward Lead-Oriented Synthesis: One-Pot Version of Castagnoli Condensation with Nonactivated Alicyclic Anhydrides

One-pot variation of Castagnoli condensation, that is, reaction of cyclic anhydrides, amines, and aldehydes, has been developed as a combinatorial approach to 1,2-disubstituted 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids, as well as their benzo-analogues. Utility of the method to multig...

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Bibliographic Details
Published in:	ACS combinatorial science Vol. 16; no. 3; pp. 146 - 153
Main Authors:	Ryabukhin, Sergey V, Panov, Dmitriy M, Granat, Dmitry S, Ostapchuk, Eugeniy N, Kryvoruchko, Dmitriy V, Grygorenko, Oleksandr O
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 10-03-2014
Subjects:	Aldehydes - chemistry Amines Amines - chemistry Anhydrides Anhydrides - chemical synthesis Anhydrides - chemistry Combinatorial analysis Combinatorial Chemistry Techniques Condensing Cut-off Hydrocarbons, Alicyclic - chemical synthesis Hydrocarbons, Alicyclic - chemistry Libraries Molecular Structure Stereoisomerism Synthesis Utilities condensation aldehyde multicomponent reaction lead-oriented synthesis anhydride amine
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