Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

To better understand the difficulties surrounding the identification of novel antibacterial compounds from corporate screening collections, physical properties of ∼3200 antibacterial project compounds with whole cell activity against Gram-negative or Gram-positive pathogens were profiled and compare...

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Bibliographic Details

Published in:	Journal of medicinal chemistry Vol. 57; no. 23; pp. 10144 - 10161
Main Authors:	Brown, Dean G, May-Dracka, Tricia L, Gagnon, Moriah M, Tommasi, Ruben
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 11-12-2014
Subjects:	Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Blood Proteins - metabolism Drug Resistance, Multiple Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects High-Throughput Screening Assays Humans Hydrophobic and Hydrophilic Interactions Microbial Sensitivity Tests Protein Binding Structure-Activity Relationship
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