Modulating Oxytocin Activity and Plasma Stability by Disulfide Bond Engineering

Disulfide bond engineering is an important approach to improve the metabolic half-life of cysteine-containing peptides. Eleven analogues of oxytocin were synthesized including disulfide bond replacements by thioether, selenylsulfide, diselenide, and ditelluride bridges, and their stabilities in huma...

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Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 53; no. 24; pp. 8585 - 8596
Main Authors:	Muttenthaler, Markus, Andersson, Asa, de Araujo, Aline D, Dekan, Zoltan, Lewis, Richard J, Alewood, Paul F
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 23-12-2010
Subjects:	Alkylation Disulfides - chemistry Drug Stability Half-Life Humans Organometallic Compounds - blood Organometallic Compounds - chemical synthesis Organoselenium Compounds - blood Organoselenium Compounds - chemical synthesis Oxidation-Reduction Oxytocin - analogs & derivatives Oxytocin - blood Oxytocin - chemical synthesis Peptidomimetics - blood Peptidomimetics - chemical synthesis Radioligand Assay Receptors, Oxytocin - metabolism Stereoisomerism Structure-Activity Relationship Sulfides - blood Sulfides - chemical synthesis Tellurium
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