Factors Determining Mutagenic Potential for Individual Cis and Trans Opened Benzo[c]phenanthrene Diol Epoxide-Deoxyadenosine Adducts

Four adducts that would result from trans opening at C-1 of benzo[c]phenanthrene 3,4-diol 1,2-epoxide (B[c]PhDE) isomers (i.e., DE-1 enantiomers, where the epoxide oxygen and benzylic hydroxyl group are cis, and DE-2 enantiomers, where they are trans) by the N6-amino group of dAdo, together with the...

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Bibliographic Details

Published in:	Biochemistry (Easton) Vol. 39; no. 14; pp. 4136 - 4144
Main Authors:	Pontén, Ingrid, Sayer, Jane M, Pilcher, Anthony S, Yagi, Haruhiko, Kumar, Subodh, Jerina, Donald M, Dipple, Anthony
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 11-04-2000
Subjects:	Animals benzo(c)phenanthrene-diol-epoxide Carcinogens - chemistry Carcinogens - toxicity DNA - drug effects DNA - genetics DNA Adducts - drug effects Humans Mutagens - toxicity Mutation Phenanthrenes - chemistry Phenanthrenes - toxicity Structure-Activity Relationship
Online Access:	Get full text
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