A Facile Method for the Solution and Solid-Phase Synthesis of Substituted [3.3.1] Bicycles

Interest in bicyclic natural products from the Guttiferae classification has led to the development of an improved method for the selenium-mediated cyclization of alkenyl-substituted β-dicarbonyls (I) to form a variety of bicyclo[3.3.1]nonan-9-ones (II) both in solution and on solid support.

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Bibliographic Details
Published in:	Organic letters Vol. 1; no. 5; pp. 807 - 810
Main Authors:	Nicolaou, K. C, Pfefferkorn, Jeffrey A, Cao, Guo-Qiang, Kim, Sanghee, Kessabi, Jilali
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 09-09-1999
Subjects:	Bridged Bicyclo Compounds - chemical synthesis Cyclization Garcinia - chemistry Indicators and Reagents Oxidation-Reduction Selenium
Online Access:	Get full text
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Description
Summary:	Interest in bicyclic natural products from the Guttiferae classification has led to the development of an improved method for the selenium-mediated cyclization of alkenyl-substituted β-dicarbonyls (I) to form a variety of bicyclo[3.3.1]nonan-9-ones (II) both in solution and on solid support.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol990791d