Griffonianone D, an Isoflavone with Anti-inflammatory Activity from the Root Bark of Millettia griffoniana

• Published in: Journal of natural products (Washington, D.C.) Vol. 66; no. 9; pp. 1288 - 1290
• Main Authors: Yankep, Emmanuel, Njamen, Dieudonné, Fotsing, Maurice Tagatsing, Fomum, Zacharias Tanee, Mbanya, Jean-Claude, Giner, Rosa M., Recio, M. Carmen, Máñez, Salvador, Ríos, José Luis
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01-09-2003
• Subjects: animal models; Animals; anti-inflammatory activity; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; bark; Blood Platelets - metabolism; Cameroon; carbon; chalcones; chemical structure; chloroform; coumarins; durmillone; Ear; edema; Edema - chemically induced; Fabaceae; Flavonoids - chemistry; Flavonoids - isolation & purification; Flavonoids - pharmacology; griffonianone; hexane; Humans; isoflavones; Isoflavones - chemistry; Isoflavones - isolation & purification; Isoflavones - pharmacology; Leukocytes - drug effects; Millettia; Millettia - chemistry; Millettia griffoniana; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; odorantin; Phospholipases A; phytochemicals; Plant Bark - chemistry; plant extracts; Plant Roots - chemistry; Plants, Medicinal - chemistry; Prostaglandin-Endoperoxide Synthases - metabolism; protons; Rats; roots; rotenoids; spectral analysis; Stereoisomerism; Cameroon
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0205912

A new isoflavone, griffonianone D (1), and the previously known compounds durmillone and odorantin were isolated from a chloroform extract of the root bark of Millettia griffoniana. The structure of 1 was established as (7E)-(6‘ ‘,7‘ ‘-dihydroxy-3‘ ‘,7‘ ‘-dimethyloct-2‘ ‘-enyl)oxy-4‘-methoxyisoflavone on the basis of its spectral data. The chloroform extract of the root bark of M. griffoniana and compound 1 showed anti-inflammatory effects in different experimental models of inflammation.