Bovine Milk Caseins and Transglutaminase-Treated Cereal Prolamins Are Differentially Recognized by IgA of Celiac Disease Patients According to Their Age

• Published in: Journal of agricultural and food chemistry Vol. 57; no. 9; pp. 3754 - 3759
• Main Authors: Cabrera-Chávez, Francisco, Rouzaud-Sández, Ofelia, Sotelo-Cruz, Norberto, Calderón de la Barca, Ana M
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 13-05-2009
• Subjects: Adolescent; Adult; age; Aging - immunology; Amino Acid Sequence; Animals; Biological and medical sciences; Bread - analysis; breads; casein; Caseins - chemistry; Caseins - immunology; Cattle; celiac disease; Celiac Disease - immunology; Cereal and baking product industries; Child; Child, Preschool; dietary protein; enzymatic treatment; Food Chemistry/Biochemistry; Food industries; Fundamental and applied biological sciences. Psychology; Glutens - chemistry; grain foods; Humans; immune response; immunoglobulin A; Immunoglobulin A - blood; Immunoglobulin A - immunology; Infant; milk; Milk - chemistry; milk analysis; Milk and cheese industries. Ice creams; milk composition; Milk, Human - chemistry; Molecular Sequence Data; patients; prolamins; Prolamins - immunology; protein-glutamine gamma-glutamyltransferase; Transglutaminases - pharmacology; Triticum - chemistry; Yogurt - analysis; Zea mays - chemistry; age-related disease; IgA reactivity; Celiac disease; prolamins; caseins; Immunopathology; Immunoglobulins; Bovine; Dairy product; Coeliac disease; Milk protein; Vertebrata; Mammalia; Casein; Intestinal malabsorption; Plant protein; Digestive diseases; Intestinal disease; Cereal; Artiodactyla; Prolamin; Ungulata; Age; Milk
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf802596g

The prevalence of celiac disease (CD) has increased worldwide, which could be related to some dietary proteins in infant regimens and/or new food processes, affecting CD-predisposed infants and older children or adults differentially. IgA reactivity to human and bovine caseins, as well as yogurt caseins and prolamins from wheat or maize breads, microbial transglutaminase (mTG)-treated or not, was evaluated in three patient groups: G1, <2 years old; G2, ∼3 years old; and G3 >8 years old. Human caseins were not recognized by IgA, whereas IgA reactivity of G2 and G3 was higher to bovine milk caseins. Immunoreactivity of G1 to yogurt caseins was lower and comparable to controls, with no effects due to mTG treatment. However, mTG treatment increased reactivity of G3 to wheat and maize prolamins. IgA immunoreactivity of CD patients to caseins and mTG-treated or not prolamins was age-dependent, which could reflect a differential manifestation of the effects of such proteins on the intestinal barrier.