Discovery of a novel class of orally active, non-peptide angiotensin II antagonists

Discovery of a novel class of orally active, non-peptide angiotensin II antagonists

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Bibliographic Details
Published in:Journal of medicinal chemistry Vol. 35; no. 20; pp. 3714 - 3717
Main Authors: De, B, Winn, M, Zydowsky, T. M, Kerkman, D. J, DeBernardis, J. F, Lee, J, Buckner, S, Warner, R, Brune, M
Format: Journal Article
Language:English
Published: United States American Chemical Society 01-10-1992
Subjects:
Administration, Oral
Angiotensin II - antagonists & inhibitors
Animals
Biphenyl Compounds - administration & dosage
Biphenyl Compounds - chemical synthesis
Biphenyl Compounds - pharmacokinetics
Imidazoles - administration & dosage
Imidazoles - chemical synthesis
Imidazoles - pharmacokinetics
Losartan
Pyrimidines - administration & dosage
Pyrimidines - chemical synthesis
Pyrimidines - pharmacokinetics
Rats
Rats, Inbred SHR
Rats, Sprague-Dawley
Structure-Activity Relationship
Tetrazoles - administration & dosage
Tetrazoles - chemical synthesis
Tetrazoles - pharmacokinetics
Online Access:Get full text
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Description
Bibliography:istex:CC12E58515A1A8AB1A737F0A6904DA82AB5A7BC4
ark:/67375/TPS-HR436281-X
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00098a018