Probing High Permeability of Nuclear Pore Complexes by Scanning Electrochemical Microscopy: Ca2+ Effects on Transport Barriers

The nuclear pore complex (NPC) solely mediates molecular transport between the nucleus and cytoplasm of a eukaryotic cell to play important biological and biomedical roles. However, it is not well-understood chemically how this biological nanopore selectively and efficiently transports various subst...

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Bibliographic Details
Published in:	Analytical chemistry (Washington) Vol. 91; no. 8; pp. 5446 - 5454
Main Authors:	Pathirathna, Pavithra, Balla, Ryan J, Jantz, Dylan T, Kurapati, Niraja, Gramm, Erin R, Leonard, Kevin C, Amemiya, Shigeru
Format:	Journal Article
Language:	English
Published:	Washington American Chemical Society 16-04-2019
Subjects:	Amino acids Atomic force microscopy Calcium ions Calcium permeability Calcium transport Chemistry Conformation Cytoplasm Effective medium theory Electrochemistry Glycine Hydrophobicity Membrane permeability Microscopy Nuclei (cytology) Organic chemistry Permeability Phenylalanine Porosity Proteins Scanning Spatial distribution Temperature Translocation Transport
Online Access:	Get full text
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