MRI Detection of VEGFR2 in Vivo Using a Low Molecular Weight Peptoid−(Gd)8-Dendron for Targeting

MRI Detection of VEGFR2 in Vivo Using a Low Molecular Weight Peptoid−(Gd)8-Dendron for Targeting

The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r 1 relaxivity of ∼48 mM−1 s−1 is show...

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Bibliographic Details
Published in:Journal of the American Chemical Society Vol. 132; no. 37; pp. 12829 - 12831
Main Authors: De León-Rodríguez, Luis M, Lubag, Angelo, Udugamasooriya, D. Gomika, Proneth, Bettina, Brekken, Rolf A, Sun, Xiankai, Kodadek, Thomas, Dean Sherry, A
Format: Journal Article
Language:English
Published: United States American Chemical Society 22-09-2010
Subjects:
Animals
Anthracenes - chemistry
Cell Line, Tumor
Gadolinium - chemistry
Humans
Magnetic Resonance Imaging
Mice
Mice, Nude
Molecular Weight
Peptoids - chemistry
Peptoids - metabolism
Vascular Endothelial Growth Factor Receptor-2 - metabolism
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Summary:The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r 1 relaxivity of ∼48 mM−1 s−1 is shown to enhance MR images of tumors grown in mice in vivo.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja105563a