Protein Binding to Lanthanide(III) Complexes Can Reduce the Water Exchange Rate at the Lanthanide

The GdIII-based magnetic resonance imaging contrast agent MS-325 targets the blood protein serum albumin, resulting in an increased efficacy (relaxivity) as a relaxation agent. MS-325 showed different relaxivities when bound to serum albumin from different species, e.g., r 1 = 30.5 mM-1 s-1 (rabbit)...

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Bibliographic Details

Published in:	Inorganic chemistry Vol. 46; no. 9; pp. 3576 - 3584
Main Authors:	Zech, Stephan G, Eldredge, Harriet B, Lowe, Mark P, Caravan, Peter
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 30-04-2007
Subjects:	Albumins - chemistry Albumins - metabolism Animals Humans Lanthanoid Series Elements - chemistry Lanthanoid Series Elements - metabolism Magnetic Resonance Spectroscopy Models, Molecular Molecular Structure Protein Binding Protons Solutions Time Factors Water - chemistry
Online Access:	Get full text
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