Effect of Glycyrrhizic Acid on Lappaconitine Phototransformation

Effect of Glycyrrhizic Acid on Lappaconitine Phototransformation

1H NMR and CIDNP methods were used to demonstrate that triterpene glycoside (glycyrrhizic acid, GA) can substantially change the efficiency and direction of phototransformation of alkaloid lappaconitine (LA) due to both its solubilization in GA micelles and protonation of LA amine nitrogen in water−...

Full description

Saved in:
Bibliographic Details
Published in:The journal of physical chemistry. B Vol. 111; no. 39; pp. 11447 - 11452
Main Authors: Kornievskaya, Valeria S, Kruppa, Alexander I, Polyakov, Nicholas E, Leshina, Tatyana V
Format: Journal Article
Language:English
Published: United States American Chemical Society 04-10-2007
Subjects:
Aconitine - analogs & derivatives
Aconitine - chemistry
Acylation
Glycyrrhizic Acid - chemistry
Magnetic Resonance Spectroscopy
Micelles
Molecular Structure
Photolysis
Protons
Solubility
Solutions
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1H NMR and CIDNP methods were used to demonstrate that triterpene glycoside (glycyrrhizic acid, GA) can substantially change the efficiency and direction of phototransformation of alkaloid lappaconitine (LA) due to both its solubilization in GA micelles and protonation of LA amine nitrogen in water−alcohol solutions. The LA solubilization in the GA micelle suppresses the process of deacylation.
Bibliography:ark:/67375/TPS-X7RT78GM-3
istex:3FF66E08199505E32DF899FDB8C949A5421A57B7
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1520-6106
1520-5207
DOI:10.1021/jp0739770